PUBLICATIONS

Kang J, Huang G, Ma L, Tong Y, Chen P, Shahapal A, Shen J. Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival. eLife 2023, 12: RP92673. PDFFigures and Figure Supplements

Montenegro P, Chen P, Kang J, Lee SH, Leone S, Shen J. Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice. Proc Natl Acad Sci USA 2023, 120 (42): e2306714120. PDF

Lee SH, Bolshakov VY, Shen J. Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus. Mol Brain 2023, 16 (17). PDF

Huang G, Bloodgood DW, Kang J, Shahapal A, Chen P, Kaganovsky K, Kim JI, Ding JB, Shen J. Motor impairments and dopaminergic defects caused by loss of LRRK function in mice. J Neurosci 2022, 42 (23): 4755-65. PDF

Cha HJ, Shen J, Kang J. Regulation of gene expression by the APP family in the adult cerebral cortex. Sci Rep 2022, 12 (66). PDF

Kang J, Watanabe H, Shen J. Protocols for assessing neurodegenerative phenotypes in Alzheimer’s mouse models. STAR Protocols 2021, 2 (3). PDF

Lee SH, Bolshakov VY, Shen J. Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity. Mol Brain 2021, 14 (85). PDF

Kang J, Shen J. Cell-autonomous role of presenilin in age-dependent survival of cortical interneurons. Mol Neurodegener 2020, 15 (72). PDF

Lee SH, Lutz D, Drexler D, Frotscher M, Shen J. Differential modulation of short-term plasticity at hippocampal mossy fiber and Schaffer collateral synapses by mitochondrial Ca2+. PLOS ONE 2020, 15 (10): e0240610. PDF

Lee SH, Kang J, Ho A, Watanabe H, Bolshakov VY, Shen J. APP family regulates neuronal excitability and synaptic plasticity but not neuronal survival. Neuron 2020, 108 (4): 676-90. PDF

Dhaliwal J, Kannangara TS, Vaculik M, Xue Y, Kumar KL, Maione A, Beique JC, Shen J, Lagace DC. Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2. Sci Rep 2018, 8 (1): 17931. PDF

Giaime E, Tong Y, Wagner LK, Yuan Y, Huang G, and Shen J (2017). Age-dependent dopaminergic neurodegeneration and impairment of the autophagyk-lysosomal pathway in LRRK-deficient mice. Neuron 2017, 96 (4): 796-807. PDF

Lee SH, Lutz D, Mossalam M, Bolshakov VY, Frotscher M, Shen J. Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway. Mol Neurodegener 2017, 12 (1): 48. PDF

Wantanabe H and Shen J. Dominant negative mechanism of Presinilin-1 mutations in FAD. Proc Natl Acad Sci USA 2017, 114 (48): 12635-7. PDF

Kang J, Shin S, Perrimon N, Shen J. An Evolutionarily conserved role of Presenilin in neuronal protection in the aging Drosophila brain. Genetics 2017, 206 (3): 1479-93. PDF

Kelleher RJ and Shen J. Presenilin-1 mutations and Alzheimer’s disease. Proc Natl Acad Sci USA 2017, 114 (4): 629-31. PDF

Xia D, Shen J, Kelleher RJ. Loss of A-beta-43 production caused by Presenilin-1 mutations in the knockin mouse brain. Neuron 2016, 90 (2): 417-22. PDF

Xia D, Watanabe H, Wu Be, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 Knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease. Neuron 2015, 85 (5): 967-81. PDF

Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res 2015, 25 (3): 394-7. PDF

Zhang C, Lee S, Peng Y, Bunker E, Giaime E, Shen J, Zhou Z, Liu X. PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions. Curr Biol 2014, 24 (16): 1854-65. PDF

Watanabe H, Iqbal M, Zhang J, Wines-Samuelson M, Shen J. Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci 2014, 34 (48): 15912-22. PDF

Lee SH, Sharma M, Südhof TC, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci USA 2014, 111 (24): 8973-8. PDF

Madeo G, Schirinzi T, Martella G, Latagliata EC, Puglisi F, Shen J, Valente EM, Federici M, Mercuri NB, Puglisi-Allegra S, Bonsi P, Pisani A. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Mov Disord 2014, 29 (1): 41-53. PDF

Shen J. Function and Dysfunction of Presenilin. Neurdegener Dis 2014, 13: 61-3. PDF

Wu B, Yamaguchi H, Lai FA, Shen J. Presenilins Regulate Calcium Homeostasis and Presynaptic Function via Ryanodine Receptors in Hippocampal Neurons. Proc Natl Acad Sci USA 2013, 110 (37): 15091-6. PDF

Yamaguchi H and Shen J. Necrosis: Methods and Protocols, book chapter “Histological Analysis of Neurodegeneration in the Mouse Brain.” Editor: Kimberly McCall, Charles Klein. Methods Mol Biol. PDF

Heilig EA, Gutti U, Taj T, Shen J, Kelleher RJ III. Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on γ-Secretase Activity and Aβ Production. J Neurosci 2013, 33 (28): 11606-17. PDF

Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Hum Mol Genet 2013, 22 (12): 2423-34. PDF

Maraver A, Fernández-Marcos PJ, Herranz D, Muñoz-Martin M, Gomez-Lopez G, Cañamero M, Mulero F, Megías D, Sanchez-Carbayo M, Shen J, Sanchez-Cespedes M, Palomero T, Ferrando A, Serrano M. Therapeutic effect of γ-secretase inhibition in KrasG12V-driven nonsmall cell lung carcinoma through derepression of DUSP1 phosphatase and inhibition of ERK. Cancer Cell 2012, 22 (2): 222-34. PDF

Giamie E, Yamaguchi H, Gauiter CA, Kitata T, Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One 2012, 7 (7): e40501. PDF

Gautier CA, Giaime E, Caballero E, Núñez L,, Song Z, Chan D, Villalobos C, Shen J. Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener 2012, 7 (22). PDF

Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of the Notch1 and Notch2 genes in excitatory neurons of the postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem 2012, 287 (24): 20356-68. PDF

Yamaguchi S, Yamane T, Takahashi-Niki K, Kato I, Niki T, Goldberg MS, Shen J, Ishimotot K, Doi T, Iguchi-Ariga SM, Ariga H. Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis. PLoS One 2012, 7 (5): e38144. PDF

Haque ME, Mount MP, Sarfarpour F, Abedel-Messih E, Callaghan S, Mazerolle C, Kitata T, Slack RS, Wallace V, Shen J, Anisman H, Park DS. Inactivation of Pink1 in vivo sensitizes dopamine producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive PD genes, Parkin or DJ-1. J Biol Chem 2012, 287 (27): 23162-70. PDF

Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knockin mice. J Neurosci 2012, 32 (15): 5085-96. PDF

Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener 2012, 7 (2). PDF

Madeo G, Martella G, Schirinzi T, Ponterio G, Shen J, Bonsi P, Pisani A. Aberrant striatal synaptic plastcity in monogenic parkinsonisms. Neuroscience 2012, 211: 126-35. PDF

Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci USA 2011, 108 (23): 9572-7. PDF

Ho A and Shen J. Presenilins in synaptic function and disease. Trends in Mol Med 2011, 17 (11): 617-24. PDF

Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, Lavoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG. Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm 2011, 118 (5): 795-808. PDF

Nakajima M, Matsuda K, Miyauchi N, Fukunaga Y, Watanabe S, Okuyama S, Pérez J, Fernández-Llebrez P, Shen J, Furukawa Y. Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages. Brain Res 2011, 1382: 275-81. PDF

Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P. Altered profile and D2-dopamine receptor modulation of high voltage-activiated calcium current in striatal medium spiny neurons from animal models of Parkinson’s disease. Neuroscience 2011, 177: 240-51. PDF

Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N. Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis 2011, 41 (1): 111-8. PDF

Kelleher RJ and Shen J. γ-Secretase and human diseases. Science 2010, 330 (6007): 1055-6. PDF

Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson’s disease-associated mutations and regulates cytoplasmic localization. Biochem J 2010, 430 (3): 393-404. PDF

Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci 2010, 30 (39): 13066-77. PDF

Pimplikar S, Nixon R, Robakis N, Shen J, Tsai LH. Amyloid-independent mechanisms of Alzheimers disease. J Neurosci 2010, 30 (45): 14946-54. PDF

Zhang D, Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J. Inactivation of presenilins causes presynaptic impairment prior to postsynaptic dysfunction. J Neurochem 2010 115: 1215-21. PDF

Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer’s disease with cotton wool plaques causes nearly complete loss of gamma-secretase activity. J Biol Chem 2010, 285 (29): 22350-9. PDF

Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J. Loss of leucine-rich reapt kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci USA 2010, 107 (21): 9879-84. PDF

Wines-Samuelson M, Schulte EC, Smith M, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in Presenilin conditional mutant mice. PLoS ONE 2010, 5 (4): e10195. PDF

Shen J. Impaired neurotransmitter release in Alzheimer’s and Parkinson’s diseases. Neurodeg Dis 2010, 7: 80-3. PDF

Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stablilized on impaired mitochondria to activate Parkin. PLoS Biol 2010, 8 (1): e10000298. PDF

Tong Y and Shen J. α-Synuclein and LRRK2: Partners in crime. Neuron 2009, 64 (6): 771-3. PDF

Yang Y, Kim A, Yamada T, Wu B, Bilimoria P, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 2009, 326 (5952): 575-8. PDF

Aoki C, Lee J, Nedelescu H, Ahmed T, Ho A, Shen J. Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. J Comp Neurol 2009, 517 (4): 512-23. PDF

Kitada T, Tong Y, Gautier C, Shen J. Absence of nigral degeneration in aged Parkin/DJ-1/PINK1 triple knockout mice. J Neurochem 2009, 111: 696-702. PDF

Shtifman A, Zhong N, Lopez JR, Shen J, Xu J. Altered Ca(2+) homeostasis in the skeletal muscle of DJ-1 null mice. Neurobiol Aging 2009, 32 (1): 125-32. PDF

Nakajima M, Watanabe S, Oduyama S, Shen J, Furukawa Y. Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage. Int J Dev Neurosci 2009, 27 (8): 837-43. PDF

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. The R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mic. Proc Natl Acad Sci USA 2009, 106 (34): 14622-7. PDF

Zhang C, Wu B, Beglopoulos V, Wines-Sanuelson M, Zhang D, Dragatsis I, Sudhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature 2009, 460: 632-6. PDF

Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D’Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P, Shen J, Guillemot F, Radtke F, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR. Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nature Neurosci 2009, 12 (7): 839-47. PDF

Giaime E, Sunyach C, Druon C, Scarzello S, Robert G, Grosso S, Auberger P, Goldberg MS, Shen J, Heutink P, Pouysségur J, Pagès G, Checler F, Alves da Costa C. Loss of function of DJ-1 triggered by Parkinson’s disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ 2009, 17: 158-69. PDF

Alves da Costa C, Sunyach C, Giaime E, West A, Corti O, Brice A, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F. Transcriptional repression of p53 by parkin and impairment by autosomal recessive juvenile Parkinson’s disease-associated mutations. Nature Cell Biol 2009, 11 (11): 1370-5. PDF

Tabuchi K, Chen G, Sudhof TC, Shen J.  Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci 2009, 29 (22): 7290-301. PDF

Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J.  Impaired dopamine release and synaptic plasticity in the striatum of parkin -/- Mice. J Neurochem 2009, 110: 613-21. PDF

Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ 3rd, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. J Biol Chem 2009, 284 (20): 13705-13. PDF

Pisani A and Shen J. Levodopa-induced dyskinesia and striatal signaling pathways. Proc Natl Acad Sci USA 2009, 106 (9): 2973-4. PDF

Baulac S, Lu H, Jennifer Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q and Xia W. Increased DJ-1 Expression under Oxidative Stress and in Alzheimer’s Disease Brains. Mol Neurodegener 2009, 4 (12). PDF

Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada, Shen J, Pisani A. Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked gene PINK1 or Parkin. Exp Neurol 2009, 215: 388-96. PDF

Hashimoto-Torii K, Torii M, Sarkisian MR, Bartley CM, Shen J, Radtke F, Gridley T, Sestan N, Rakic P. Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex. Neuron 2008, 60 (2): 273-84. PDF

Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W. LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res 2008, 314: 2055-65. PDF

Gautier CA, Kitada T, Shen J. Loss of PINK1 Causes Mitochondrial Functional Defects and Increased Sensitivity to Oxidative Stress. Proc Natl Acad Sci USA 2008, 105 (32): 11364-9. PDF

Kim WY and Shen J. Presenilins are required for maintenance of neural stem cells in the developing brain. Mol Neurodegener 2008, 3 (2). PDF

Shen J., Kelleher RJ 3rd. The presenilin hypothesis of Alzheimer’s disease: Evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci USA 2007, 104 (2): 403-9. PDF

Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC. Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci USA 2008, 105 (3): 979-84. PDF

Cookson MR, Dauer W, Dawson T, Fon E, Guo M, Shen J. The roles of kinases in familial Parkinson’s disease. J Neurosci 2007, 27 (44): 11865-8. PDF

Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk D, LiS, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, and Richardson WD. A regulatory network involving Foxn4, Mash-1 and Delta-like 4/Notch-1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development 2007, 134: 3427-36. PDF

Maraver A., Tadokoro CE, Badura ML, Shen J, Serrano M, and Lafaille JJ. Effect of Presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood 2007, 110 (9): 3218-25. PDF

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, and Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci USA. 2007, 104 (27): 11441-6. PDF

Yamaguchi H and Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener 2007, 2 (10). PDF

Kuo CT, Mirzadeh Z, Sorino-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN. Postnatal Deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 2006, 127: 1253-64. PDF

Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberd MS, Schlossmacher MG, Shen J, Querfurth HW. Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells. J Biol Chem 2006, 281 (18): 12809-16. PDF

Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Shen J, and Calabresi P. Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase. Neurobiol of Dis 2006, 23: 54-60. PDF

Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey M,  Kopan R, and Shen J. Notch1 Signaling Influences V2 Interneuron and Motor Neuron Development in the Spinal Cord. Dev Neurosci 2006, 28: 102-17. PDF

Beglopoulos V and Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer’s disease. Trends Pharmacol Sci 2006, 27 (1): 33-40. PDF

Grimm MOW, Grimm HS, Patzold AJ, Zinser EG, Halonen R, Duering M, Tschape JA, Muller U, De Strooper B, Shen J, Hartmann T.  Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol 2005, 7 (11): 1118-23. PDF

Pan Y, Liu Z, Shen J and Kopan R. Notch 1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol 2005, 286 (2): 472-82. PDF

Sun X, Beglopoulos V, Mattson M and Shen J. Hippocampal spatial memory impairments caused by familial Alzheimer’s disease-linked presenilin-1 M146V mutation. Neurodegener Dis 2005, 2 (1): 6-15. PDF

Saura CA, Chen G, Malkani S, Choi S, Takahashi RH, Gouras GK, Kirkwood A, Morris RGM and Shen J. Conditional inactivation of presenelin-1 prevents amyloid accumulation and temporarily rescues associative and working memory impairments in APP transgenic mice. J Neurosci 2005, 25 (29): 6755-64. PDF

Wines-Samuelson M and Shen J. Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist 2005, 11 (5): 441-51. PDF

Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, da Costa CA, Vincent B, Ring S, D’Adamio L, Shen J, Muller U, Hyslop P, Checler F. Presenilin dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 2005, 46: 541-54. PDF

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, and Parker EM. Characterization of the reconstituted gamma-secretase complex from Sf9 co-expressing presenilin-1, nacastrin, Aph-1a, and pen-2. Biochemistry 2005, 44: 4450-57. PDF

Wines-Samuelson ME, Handler M and Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol 2005, 277 (2): 332-46. PDF

Goldberg MS, Pisani A, Haburcak M, Vortherms, TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P and Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1. Neuron 2005, 45: 489-96. PDF

Beglopoulos V and Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromolecular Med 2004, 6: 13-30. PDF

Shen J. Protein kinases linked to the pathogenesis of Parkinson’s disease. Neuron 2004, 44: 575-7. PDF

Pan Y, Lin M, Tian X, Cheng H, Gridley T, Shen J, Kopan R. γ-Secretase functions through Notch signaling to maintain the lineally related skin appendages but is not required for patterning or their initial morphogenesis. Dev Cell 2004, 7 (5): 731-43. PDF

Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD and Shen J. Reduced B-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knockout Mice. J Biol Chem 2004, 279 (45): 46907-14. PDF

Shen J, Cookson MR. Mitochondria and Dopamine: New Insights into Recessive Parkinsonism. Neuron 2004, 43 (3): 301-4. PDF

Saura CA, Choi S, Beglopoulos V,  Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher III RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration. Neuron 2004, 42 (1): 23-36. PDF

Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Klose J, and Shen J. Mitochondrial Dysfunction and Oxidative Damage in Parkin-Deficient Mice. J Biol Chem 2004, 279 (18): 18614-22. PDF

Yang X, Klein R, Tian X, Cheng H, Kopan R, Shen J. Notch Activation Induces Apoptosis in Neural Progenitor Cells through a p53-Dependent Pathway. Dev Biol 2004, 269 (1): 81-94. PDF

Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet M, Maidment NT, Levine MS, Shen J. Parkin-Deficient Mice Exhibit Nigrostriatal Deficits but not Loss of Dopaminergic Neurons. J Biol Chem 2003, 278 (44): 43628-35. PDF

Fujiwara H, Hasegawa M, Dohmae N, Kawashia A, Masliah E, Goldberg MS, Shen J, Takio K, Iwasubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002, 4 (2): 160-4. PDF

Yu H, Saura C, Choi S, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel E, Kirkwood A, Shen J. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 2001, 31 (5): 713-26. PDF

Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. Alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci USA 2001, 98 (16): 9110-5. PDF

Singh N, Talalayeva Y, Tsiper M, Romanov V, Dranovsky A, Colflesh D, Rudamen G, Vitek MP, Shen J, Yang S, Goldgaber D, Schwarzman AL. The role of Alzheimer’s disease-related presenilin 1 in intercellular adhesion. Exp Cell Res 2001, 263 (1): 1-13. PDF

Yang X, Handler M, Shen J. Role of presenilin-1 in murine neural development. Ann NY Acad Sci 2000, 920: 165-70. PDF

Yoo AS, Cheng I, Chung, S, Grenfell TZ, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated molulation of capacitative calcium entry. Neuron 2000, 27 (3): 561-72. PDF

Handler M, Yang X, Shen J. Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 2000, 127 (12): 2593-606. PDF

Yu H, Kessler J, Shen J. Heterogeneous populations of ES cells in the generation of a floxed Presenilin-1 allele. Genesis 2000, 26: 5-8. PDF

Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci USA 1999, 96 (12): 6959-63. PDF

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin regulates the processing of APP C-terminal fragments and the generation of amyloid §-protein in ER and Golgi. Biochemistry 1998, 37 (47): 16465-71. PDF

Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1 deficient mice. Cell 1997, 89 (4): 629-39. PDF

Shen J, Zu K, Cass C, Beyer A, Hirsh J. Exon skipping by overexpression of a Drosophila heterogeneous nuclear ribonucleaoprotein in vivo. Proc Natl Acad Sci USA 1995, 92 (6): 1822-25. PDF

Shen J, Hirsh J. Cis-regulatory sequences responsible for alternative splicing of the Drosphila dopa decarboxylase gene. Mol Cell Biol 1994, 14 (11): 7385-93. PDF

Shen J, Beall CJ, Hirsh J. Tissue-specific alternative splicing of the Drosophilia dopa decarboxylase gene is affected by heat shock. Mol Cell Biol 1993, 13 (8): 4549-55. PDF