2011 – 2015

| < 2000 | 2001 – 2005  |  2006 – 2010  | 2011 – 2015 | 2016 – 2020 | 2021 – 2023 |

Xia D, Watanabe H, Wu Be, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ*. Presenilin-1 Knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease. Neuron 2015, 85:96-81.

Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res 2015, 25:394-7.

Zhang C, Lee S, Peng Y, Bunker E, Giaime E, Shen J, Zhou Z, Liu X. PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions. Curr Biol 2014, 24:1854-65.

Watanabe H, Iqbal M, Zhang J, Wines-Samuelson M, Shen J. Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci 2014, 15912-22.

Lee SH, Sharma M, Südhof TC, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci USA 2014, 111:8973-8.

Madeo G, Schirinzi T, Martella G, Latagliata EC, Puglisi F, Shen J, Valente EM, Federici M, Mercuri NB, PugLee SH, Sharma M, Südof TC, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci USA 2014, 111:8973-8.

Madeo G, Schirinzi T, Martella G, Latagliata EC, Puglisi F, Shen J, Valente EM, Federici M, Mercuri NB, Puglisi-Allegra S, Bonsi P, Pisani A. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Mov Disord 2014, 29:41-53.

Shen J. Function and Dysfunction of Presenilin. Neurdegener Dis 2014, 13:61-3.

Wu B, Yamaguchi H, Lai FA, Shen J. Presenilins Regulate Calcium Homeostasis and Presynaptic Function via Ryanodine Receptors in Hippocampal Neurons. Proc Natl Acad Sci USA 2013, 110:15091-6.

Yamaguchi H and Shen J. Necrosis: Methods and Protocols, book chapter “Histological Analysis of Neurodegeneration in the Mouse Brain.” Editor: Kimberly McCall, Charles Klein. Methods Mol Biol.

Heilig EA, Gutti U, Taj T, Shen J, Kelleher RJ III. Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on γ-Secretase Activity and Aβ Production. J Neurosci 2013, 33:11606-17.

Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Hum Mol Genet 2013, 22:2423-34.

Maraver A, Fernández-Marcos PJ, Herranz D, Muñoz-Martin M, Gomez-Lopez G, Cañamero M, Mulero F, Megías D, Sanchez-Carbayo M, Shen J, Sanchez-Cespedes M, Palomero T, Ferrando A, Serrano M. Therapeutic effect of γ-secretase inhibition in KrasG12V-driven nonsmall cell lung carcinoma through derepression of DUSP1 phosphatase and inhibition of ERK. Cancer Cell 2012, 22:222-34.

Giamie E, Yamaguchi H, Gauiter CA, Kitata T, Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One 2012, 7:e40501.

Gautier CA, Giaime E, Caballero E, Núñez L,, Song Z, Chan D, Villalobos C, Shen J. Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener 2012, 7:22.

Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of the Notch1 and Notch2 genes in excitatory neurons of the postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem 2012, 287:20356-68.

Yamaguchi S, Yamane T, Takahashi-Niki K, Kato I, Niki T, Goldberg MS, Shen J, Ishimotot K, Doi T, Iguchi-Ariga SM, Ariga H. Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis. PLoS One 2012, 7:e38144.

Haque ME, Mount MP, Sarfarpour F, Abedel-Messih E, Callaghan S, Mazerolle C, Kitata T, Slack RS, Wallace V, Shen J, Anisman H, Park DS. Inactivation of Pink1 in vivo sensitizes dopamine producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive PD genes, Parkin or DJ-1. J Biol Chem 2012, 287:23162-70.

Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knockin mice. J Neurosci 2012, 32:5085-5096.

Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener 2012, 7:2.

Madeo G, Martella G, Schirinzi T, Ponterio G, Shen J, Bonsi P, Pisani A. Aberrant striatal synaptic plastcity in monogenic parkinsonisms. Neuroscience 2011, 211:126-35.

Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci USA 2011, 108:9572-7.

Ho A and Shen J. Presenilins in synaptic function and disease. Trends in Mol Med 2011, 17:617-24.

Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, Lavoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG. Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm 2011, 118:795-808.

Nakajima M, Matsuda K, Miyauchi N, Fukunaga Y, Watanabe S, Okuyama S, Pérez J, Fernández-Llebrez P, Shen J, Furukawa Y. Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages. Brain Res 2011, 1382:275-81.

Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P. Altered profile and D2-dopamine receptor modulation of high voltage-activiated calcium current in striatal medium spiny neurons from animal models of Parkinson’s disease. Neuroscience 2011, 177:240-51.

Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N. Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis 2011, 41:111-8.

| < 2000 | 2001 – 2005  |  2006 – 2010  | 2011 – 2015 | 2016 – 2020 | 2021 |

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