2001 – 2005

| < 2000 | 2001 – 2005  |  2006 – 2010  | 2011 – 2015 | 2016 – 2020 | 2021 – 2023 |

Grimm MOW, Grimm HS, Patzold AJ, Zinser EG, Halonen R, Duering M, Tschape JA, Muller U, De Strooper B, Shen J, Hartmann T.  Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol 2005, 7:Letter.

Pan Y, Liu Z, Shen J and Kopan R. Notch 1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol 2005, 286:472-82.

Sun X, Beglopoulos V, Mattson M and Shen J. Hippocampal memory impairments caused by familial Alzheimer’s disease-linked M146V mutation. Neurodegener Dis 2005, 5:6-1.

Saura CA, Chen G, Malkani S, Choi S, Takahashi RH, Gouras GK, Kirkwood A, Morris RGM and Shen J. Conditional inactivation of presenelin-1 prevents amyloid accumulation and temporarily rescues associative and working memory impairments in APP transgenic mice. J Neurosci 2005, 20:6755-64.

Wines-Samuelson M and Shen J. Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist 2005,11:441-51.

Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, da Costa CA, Vincent B, Ring S, D’Adamio L, Shen J, Muller U, Hyslop P, Checler F. Presenilin dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 2005, 46:541-554.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, and Parker EM. Characterization of the reconstituted gamma-secretase complex from Sf9 co-expressing presenilin-1, nacastrin, Aph-1a, and pen-2. Biochemistry 2005, 44:4450-4457.

Wines-Samuelson ME, Handler M and Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol 2005, 277: 332-346.

Goldberg MS, Pisani A, Haburcak M, Vortherms, TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P and Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1. Neuron 2005, 45:489-96.

Beglopoulos V and Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromolecular Med 2004, 6:13-30.

Shen J. Protein kinases linked to the pathogenesis of Parkinson’s disease. Neuron 2004, 44:575-7.

Pan Y, Lin M, Tian X, Cheng H, Gridley T, Shen J, Kopan R. γ-Secretase functions through Notch signaling to maintain the lineally related skin appendages but is not required for patterning or their initial morphogenesis. Dev Cell 2004, 7:731-743.

Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD and Shen J. Reduced B-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knockout Mice. J Biol Chem 2004, 279:46907-14.

Shen J, Cookson MR. Mitochondria and Dopamine: New Insights into Recessive Parkinsonism. Neuron 2004, 43:301-4.

Saura CA, Choi S, Beglopoulos V,  Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher III RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration. Neuron 2004, 42: 23-36.

Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Klose J, and Shen J. Mitochondrial Dysfunction and Oxidative Damage in Parkin-Deficient Mice. J Biol Chem 2004, 279:18614-22.

Yang X, Klein R, Tian X, Cheng H, Kopan R, Shen J. Notch Activation Induces Apoptosis in Neural Progenitor Cells through a p53-Dependent Pathway. Dev Biol 2004, 269:81-94.

Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet M, Maidment NT, Levine MS, Shen J. Parkin-Deficient Mice Exhibit Nigrostriatal Deficits but not Loss of Dopaminergic Neurons. J Biol Chem 2003, 278:43628-35.

Fujiwara H, Hasegawa M, Dohmae N, Kawashia A, Masliah E, Goldberg MS, Shen J, Takio K, Iwasubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002, 4: 160-4.

Yu H, Saura C, Choi S, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel E, Kirkwood A, Shen J. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 2001, 31:713-26.

Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. Alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci USA 2001, 98:9110-5.

Singh N, Talalayeva Y, Tsiper M, Romanov V, Dranovsky A, Colflesh D, Rudamen G, Vitek MP, Shen J, Yang S, Goldgaber D, Schwarzman AL. The role of Alzheimer’s disease-related presenilin 1 in intercellular adhesion. Exp Cell Res 2001, 263:1-13.

| < 2000 | 2001 – 2005  |  2006 – 2010  | 2011 – 2015 | 2016 – 2020 | 2021 |