2006 – 2010

| < 2000 | 2001 – 2005  |  2006 – 2010  | 2011 – 2015 | 2016 – 2020 | 2021 – 2023 |

Kelleher RJ and Shen J. γ-Secretase and human diseases. Science 2010, 330:1055-6.

Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P. Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson’s disease. Neuroscience 2010, 177:240-51.

Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson’s disease-associated mutations and regulates cytoplasmic localization. Biochem J 2010, 430:393-404.

Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci 2010, 30:13066-77.

Pimplikar S, Nixon R, Robakis N, Shen J, Tsai LH. Amyloid-independent mechanisms of Alzheimers disease. J Neurosci 2010, 30:14946-54.

Zhang D, Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J. Inactivation of presenilins causes presynaptic impairment prior to postsynaptic dysfunction. J Neurochem 2010 115:1215-21.

Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer’s disease with cotton wool plaques causes nearly complete loss of gamma-secretase activity. J. Biol Chem 2010, 285:22350-9.

Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J. Loss of leucine-rich reapt kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci USA 2010, 107:9879-84.

Wines-Samuelson M, Schulte EC, Smith M, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in Presenilin conditional mutant mice. PLoS ONE 2010, 5:e10195.

Shen J. Impaired neurotransmitter release in Alzheimer’s and Parkinson’s diseases. Neurodeg Dis 2010, 7:80-83.

Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stablilized on impaired mitochondria to activate Parkin. PLoS Biol 2010, 8:e10000298.

Tong Y and Shen J. α-Synuclein and LRRK2: Partners in crime. Neuron 2009, 64:771-773.

Yang Y, Kim A, Yamada T, Wu B, Bilimoria P, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 2009, 326:575-8.

Aoki C, Lee J, Nedelescu H, Ahmed T, Ho A, Shen J. Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. J Comp Neurol 2009, 517:512-23.

Kitada T, Tong Y, Gautier C, Shen J. Absence of nigral degeneration in aged Parkin/DJ-1/PINK1 triple knockout mice. J Neurochem 2009, 111:696-702.

Shtifman A, Zhong N, Lopez JR, Shen J, Xu J. Altered Ca(2+) homeostasis in the skeletal muscle of DJ-1 null mice. Neurobiol Aging 2009, 32:125-32.

Nakajima M, Watanabe S, Oduyama S, Shen J, Furukawa Y. Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage. Int J Dev Neurosci 2009, 27:837-43.

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. The R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mic. Proc Natl Acad Sci USA 2009, 106:14622-7.

Zhang C, Wu B, Beglopoulos V, Wines-Sanuelson M, Zhang D, Dragatsis I, Sudhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature 2009, 460:632-6.

Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D’Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P, Shen J, Guillemot F, Radtke F, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR. Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nature Neurosci 2009, 12:839-47.

Giaime E, Sunyach C, Druon C, Scarzello S, Robert G, Grosso S, Auberger P, Goldberg MS, Shen J, Heutink P, Pouysségur J, Pagès G, Checler F, Alves da Costa C. Loss of function of DJ-1 triggered by Parkinson’s disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ 2009, 17:158-69.

Alves da Costa C, Sunyach C, Giaime E, West A, Corti O, Brice A, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F. Transcriptional repression of p53 by parkin and impairment by autosomal recessive juvenile Parkinson’s disease-associated mutations. Nature Cell Biol 2009, 11:1370-5.

Tabuchi K, Chen G, Sudhof TC, Shen J.  Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.  J Neurosci 2009, 29:7290-301.

Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J.  Impaired dopamine release and synaptic plasticity in the striatum of parkin -/- Mice.  J Neurochem 2009, 110:613-21.

Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ 3rd, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. J Biol Chem 2009, 284:13705.

Pisani A and Shen J. Levodopa-induced dyskinesia and striatal signaling pathways. Proc Natl Acad Sci USA 2009, 106:2973-4.

Baulac S, Lu H, Jennifer Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q and Xia W. Increased DJ-1 Expression under Oxidative Stress and in Alzheimer’s Disease Brains. Mol Neurodegen 2009, 4:12.

Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada, Shen J, Pisani A. Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked gene PINK1 or Parkin. Exp Neurol 2009, 215:388-96.

Hashimoto-Torii K, Torii M, Sarkisian MR, Bartley CM, Shen J, Radtke F, Gridley T, Sestan N, Rakic P. Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex. Neuron 2008, 60:273-84.

Hashimoto-Torii K, Torii M, Sarkisian MR, Bartley CM, Shen J, Radtke F, Gridley T, Sestan N, Rakic P. Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex. Neuron 2008, 60:273-84.

Shen J., Kelleher RJ 3rd. The presenilin hypothesis of Alzheimer’s disease: Evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci USA 2007, 104:409.

Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W. LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res 2008, 314:2055-65.

Gautier CA, Kitada T, Shen J. Loss of PINK1 Causes Mitochondrial Functional Defects and Increased Sensitivity to Oxidative Stress. Proc Natl Acad Sci USA 2008, 105:11364-11369.

Kim WY and Shen J. Presenilins are required for maintenance of neural stem cells in the developing brain. Molecular Neurodegeneration 2008, 3:2.

Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC. Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci USA 2008, 105:979-984.

Cookson MR, Dauer W, Dawson T, Fon E, Guo M, Shen J. The roles of kinases in familial Parkinson’s disease. J Neurosci 2007, 27:11865-8.

Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk D, LiS, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, and Richardson WD. A regulatory network involving Foxn4, Mash-1 and Delta-like 4/Notch-1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development 2007, 134:3427-36.

Maraver A., Tadokoro CE, Badura ML, Shen J, Serrano M, and Lafaille JJ. Effect of Presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood 2007, 110:3218-25.

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, and Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci USA. 2007, 104:11441-6.

Yamaguchi H and Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular Neurodegeneration 2007, 2:10.

Kuo CT, Mirzadeh Z, Sorino-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN. Postnatal Deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 2006, 127:1253-64.

Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberd MS, Schlossmacher MG, Shen J, Querfurth HW. Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells. J Biol Chem 2006, 281:12809-16.

Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Shen J, and Calabresi P. Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase. Neurobiol of Dis 2006, 23:54-60

Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey M,  Kopan R, and Shen J. Notch1 Signaling Influences V2 Interneuron and Motor Neuron Development in the Spinal Cord. Dev Neurosci 2006, 28:102-117.

Beglopoulos V and Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer’s disease. Trends Pharm Sci 2006, 27:33-40.

| < 2000 | 2001 – 2005  |  2006 – 2010  | 2011 – 2015 | 2016 – 2020 | 2021 |

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